Introduction Transforming care Investing in our people Accelerating possibilities Protecting the environment Creating value responsibly Appendix A message from our Chairman and Chief Executive Officer At Boston Scientific, our purpose is advancing science for life — a purpose shared by our more than 45,000 employees around the world. This commitment is a result of a values-driven culture that aims to create a brighter and healthier future for patients, communities and our planet. Our 2022 environmental, social and governance results demonstrate high performance across our company. Our global teams navigated supply chain disruption, expanded our digital and operational capabilities, and fueled our pipeline by investing more than 10% of our sales into research 1 and development. We took action to address inequities in the workplace, communities and health care systems. Because a healthier planet leads to healthier people, we made steady progress toward our 2030 commitment 2 for carbon neutrality and received approval of our science-based emission reduction targets that will help guide our path to net-zero greenhouse gas emissions across our entire value chain by 2050. Most importantly, we worked together to help improve the lives of more than 33 million patients around the world. We have much more to do and will always raise the bar to hold ourselves accountable for progress. I know the culture we have built will continue to serve us well as we work together to transform lives around the world through innovative medical solutions. " At Boston Scientific, our commitment is a result of a Mike Mahoney values-driven culture that aims to create a brighter and Chairman and Chief Executive Officer, healthier future for patients, communities and our planet." Boston Scientific 1 Represents GAAP R&D expense as a percent of GAAP net sales per 2022 Annual Report on Form 10-K. 2 Inclusive of all manufacturing and key distribution sites only (scopes 1 and 2). 5 2022 Performance Report