Introduction Transforming care Investing in our people Accelerating possibilities Protecting the environment Creating value responsibly Appendix Closing the gap in care and outcomes Increasing diversity in medical research We know that health inequities lead to poorer patient outcomes, Diversity in medical research is essential to ensuring everyone and our Close the Gap team works to address them through a who needs care can benefit from treatments and therapies. comprehensive health equity strategy. In the United States, the In 2022, the U.S. Food and Drug Administration (FDA) released team works closely with providers and organizations in local draft guidelines for diversity in clinical trials, affirming the ELEGANCE inclusion milestones communities to raise awareness about racial and gender biases need for inclusive representation. Beginning in 2014 with the that contribute to disparities in heart and vascular care and also Platinum Diversity Trial, our longstanding work to increase to advocate for inclusive clinical trial representation. clinical trial diversity now includes the ELEGANCE patient Enrollment 2022 enrollment registry and post-market study for patients diagnosed with goal: progress: Partnering with providers. Disease prevalence data can help peripheral artery disease (PAD), which disproportionately affects providers improve their outreach to underserved patients. Black men and women. Through 2022, we have surpassed our 40%+ 43% In 2022, at the request of community providers, the Close the ELEGANCE diversity goal. To date, there are 43% women and women women Gap team generated local U.S. disparity index data on disease 47% underrepresented minorities enrolled in the registry. prevalence and treatment inequities. We identified more than 40%+ 47% 121,000 women and people of color who may not have access to equitable heart and vascular care, and collaborated with underrepresented underrepresented providers to create health action plans that address disparities minorities minorities and promote equity in underserved communities. Raising awareness. To address health inequities, the Close the Gap team held health education summits on heart and vascular disease in Atlanta, Georgia and Charlotte, North Carolina in collaboration with Black Health Matters and Omega Psi Phi Fraternity Inc., one of the oldest U.S. historically Black fraternities. Participants reported a 99% increase in their familiarity with cardiovascular disease risk factors and treatment options after the sessions. 33 2022 Performance Report