Introduction Transforming care Investing in our people Accelerating possibilities Protecting the environment Creating value responsibly Appendix Indicator Description Response 2-21 Annual total compensation ratio Proxy Statement 2-22 Statement on sustainable development strategy Performance Report, A message from our Chairman and Chief Executive Officer, Page 5 Form 10-K, Item 1. Business Strategy, Page 3 Performance Report, Our ESG strategy and priorities, Page 8 2-23 Policy commitments Performance Report, Our mission and values, Page 6 Code of Conduct Respecting human rights Performance Report, Creating value responsibly, Page 47 2-24 Embedding policy commitments Respecting human rights Compliance and ethics 2-25 Processes to remediate negative impacts Compliance and ethics 2-26 Mechanisms for seeking advice and raising concerns Advice line Boston Scientific adheres to all compliance requirements, see compliance references throughout the Performance Report and Bostonscientific.com 2-27 Compliance with laws and regulations Form 10-K, Item 1. Regulatory Environment, Page 9 Form 10-K, Item 8. Financial Statements and Supplementary Data, Note I - Commitments and Contingencies, Page 103 Performance Report Appendix, Metrics summary 2-28 Membership associations Trade association memberships 2-29 Approach to stakeholder engagement Performance Report, Our ESG strategy and priorities, Page 8 Performance Report Appendix, Stakeholder engagement, Page 58 2-30 Collective bargaining agreements Human rights, collective bargaining GRI 3: Material topics 2021 3-1 Process to determine material topics Performance Report Appendix, Materiality, Page 57 3-2 List of material topics Performance Report Appendix, Materiality, Page 57 Form 10-K, Item 1. Business, Page 3 3-3 Management of material topics Performance Report, Our ESG strategy and priorities, Page 8 Performance Report Appendix, Materiality, Page 57 70 2022 Performance Report