Income Statement Information Non-GAAP Reconciliation Year Ended December 31, 2022 (unaudited) Acquisition Restructuring / and Intangible Divestitures- Restructuring Litigation- Investment Asset Related -Related Net Related Net Portfolio EU MDR Debt Deferred Tax GAAP Amortization Impairment Charges Charges Charges Net Losses Implementation Extinguishment Expenses Discrete Tax Adjusted* In millions, except per share data Results Expense Charges (Credits) (Credits) (Credits) (Gains) Costs Charges (Benefits) Items Results Net sales $ 12,682 — — — — — — — — — — $ 12,682 Cost of products sold 3,956 — — 97 65 — — 46 — — — 3,747 Gross profit 8,727 — — (97) (65) — — (46) — — — 8,935 Gross margin 68.8 % 70.5 % Selling, general and administrative expenses 4,520 — — 110 21 — — 2 — — — 4,387 SG&A as a percentage of sales 35.6 % 34.6 % Research and development expenses 1,323 — — 40 — — — 24 — — — 1,260 R&D as a percentage of sales 10.4 % 9.9 % Royalty expense 47 — — — — — — — — — — 47 Royalty expense as a percentage of sales 0.4 % 0.4 % Amortization expense 803 803 — — — — — — — — — — Intangible asset impairment charges 132 — 132 — — — — — — — — — Contingent consideration net expense (benefit) 35 — — 35 — — — — — — — — Restructuring net charges (credits) 24 — — — 24 — — — — — — — Litigation-related net charges (credits) 173 — — — — 173 — — — — — — Losses (gains) on disposal of businesses and assets 22 — — 22 — — — — — — — — 7,078 803 132 206 45 173 — 25 — — — 5,694 Operating Income (loss) 1,649 (803) (132) (303) (110) (173) — (71) — — — 3,241 Operating margin 13.0 % 25.6 % Other income (expense): Interest expense (470) — — — — — — — (194) — — (276) Other, net (38) — — 18 — — 30 — — — — (86) Income (loss) before taxes 1,141 (803) (132) (285) (110) (173) 30 (71) (194) — — 2,880 Income tax expense (benefit) 443 (109) (29) 53 (14) (40) 2 (10) (45) 140 129 366 Net Income (loss) $ 698 $ (694) $ (102) $ (338) $ (96) $ (133) $ 28 $ (62) $ (149) $ (140) $ (129) $ 2,514 Preferred stock dividends (55) $ (55) Net Income (loss) available to common stockholders 642 $ (694) $ (102) $ (338) $ (96) $ (133) $ 28 $ (62) $ (149) $ (140) $ (129) $ 2,459 Net Income (loss) per diluted common share $ 0.45 $ (0.48) $ (0.07) $ (0.24) $ (0.07) $ (0.09) $ 0.02 $ (0.04) $ (0.10) $ (0.10) $ (0.09) $ 1.71 Weighted average diluted shares outstanding 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 1,439.7 For the year ended December 31, 2022, the effect of assuming the conversion of MCPS into shares of common stock was anti-dilutive, and therefore excluded from the calculation of EPS. Accordingly, GAAP net income and adjusted net income were reduced by cumulative Preferred stock dividends, as presented in our unaudited consolidated statements of operations, for purposes of calculating net income available to common stockholders. 10 Margin rates are based on actual, non-rounded amounts and may not recalculate precisely. Q4 2022 Financial & Operational Highlights | February 1, 2023