Appendix C - Additional Non-GAAP Reconciliations 12 Months Ended Reconciliation of Debt to Adjusted EBITDA (in millions) Q1 2022 Q2 2022 Q3 2022 Q4 2022 12/31/2022 Net income (loss) $ 110 $ 260 $ 188 $ 140 $ 698 Income tax (benefit) expense 45 85 57 256 443 Interest expense 279 64 63 64 470 Interest income (4) (1) (1) (4) (10) Depreciation expense 76 80 82 94 333 Amortization expense 198 204 202 199 803 EBITDA 705 692 590 750 2,737 Non-GAAP Adjustments Restructuring and restructuring-related net charges (credits) 29 35 18 28 110 Intangible asset impairment charges — 7 125 — 132 Investment portfolio net losses (gains) 7 4 (3) (38) (30) Acquisition/divestiture - related net charges (credits) 72 91 113 9 285 Litigation-related net charges (credits) — 42 — 131 173 EU MDR implementation costs 16 17 20 19 71 Adjusted EBITDA $ 829 $ 887 $ 862 $ 900 $ 3,478 Debt $ 8,935 Debt to Adjusted EBITDA 2.57x 24 Q4 2022 Financial & Operational Highlights | February 1, 2023