Introduction Transforming care Investing in our people Accelerating possibilities Protecting the environment Creating value responsibly Appendix Transforming care We take on the most complex challenges in health care. Inspired by patients and the promise of innovation, we shape science 33+ million into solutions to help people live longer, patients served better lives. $1.3+ billion invested in R&D1 In this section: Zero findings • Innovating to meet more patient needs resulting in action following 325+ external audit days • Ensuring quality, health and safety • Improving patient outcomes through digital solutions 1 Represents GAAP R&D expense per 2022 Annual Report on Form 10-K. 12 2022 Performance Report