Introduction Transforming care Investing in our people Accelerating possibilities Protecting the environment Creating value responsibly Appendix Overview and 2022 highlights Innovating to meet more Policies and related links With health care needs continuing to grow globally, making a patient needs difference for more people required our teams to challenge what How we approach quality was possible. Our people upheld rigorous quality processes, Our approach to innovation identifies new treatments for delivered market-leading solutions around the world and urgent health needs and enhancements that make our existing collaborated with early-stage innovators, partners in health products even better. Boston Scientific teams excel in this work equity and practitioners in the field to expand health care because for us, innovation is a mindset we share. Our best access. To further improve patient outcomes, we strengthened inventions come from the diverse perspectives of our people as our digital platforms and solutions to enhance health care they advance science to uncover potential solutions and then Why it matters professional education and increased the use of remote implement rigorous research and development (R&D). With our patient monitoring. strong pace of innovation, 33% of total company net sales in 2022 When patient outcomes improve came from products released over the past three years, inclusive because of our products, more of products new to Boston Scientific that were acquired through providers turn to us for quality strategic acquisitions. solutions. By finding new ways to 1 Represents GAAP R&D expense per 2022 Annual Report on Form 10-K. enhance those innovations and 2 Represents GAAP R&D expense as a percent of GAAP net sales per 2022 Annual Report expand access through digital on Form 10-K. advances, we help even more 2022 innovation results people lead healthier lives. 33+ million patients served $1.3+ billion invested in R&D1 10.4% 2 R&D spend as percent of sales 13 2022 Performance Report