Introduction Transforming care Investing in our people Accelerating possibilities Protecting the environment Creating value responsibly Appendix Boston Scientific: 2022 at a glance 2022 net sales by region (dollars in millions) Boston Scientific transforms lives through innovative medical solutions that improve the health of patients around the world. U.S. $7,632 As a global medical technology leader for more than 40 years, EMEA (Europe, Middle East and Africa) $2,526 we advance science for life by providing a broad range of high- APAC (Asia-Pacific) $2,116 $12,682 performance solutions that address unmet patient needs and million reduce the cost of health care. LACA (Latin America and Canada) $469 To learn more about our category leadership strategy and $12,742 1 growth opportunities, visit our Investor Relations website. Other (60) Net Sales $12,682 2 1 Reflects sales reserves established for Italian government payback provisions not allocated to reportable segments. 2022 net sales by business (dollars in millions) Cardiovascular MedSurg Cardiology Peripheral Endoscopy Urology Neuromodulation Interventions $5,932 $1,899 $2,221 $1,773 $917 Cardiac Rhythm Electrophysiology Interventional Watchman Management Cardiology Therapies 2 In the first quarter of 2022, we reorganized our operational structure and have aggregated our core businesses, each of which generate revenues from the sale of medical devices, into two reportable segments comprised of MedSurg and Cardiovascular. Within the Cardiovascular segment, the newly formed Cardiology division represents the combined former Rhythm Management and Interventional Cardiology businesses. We have revised prior period amounts to conform to the current year presentation. 7 2022 Performance Report